Investigation of Angiogenesis a Prime Cancer Hallmark: Study Model and Technique for Product Development Assessment

Assessment

A new cancer research biotech company has commissioned you to write a briefing report around study models and techniques relevant for a specific hallmark of your choice, in order to set up a line of products. Drawing from the literature, present and critically evaluate one study model and one experimental technique that can be used the scientific investigation of this hallmark of cancer, supporting your report with literature-derived images. Drawing from the information you have collected, propose one original experiment using the study model and one experimental technique you have presented, which would support the investigation on the hallmark of cancer chosen.

Sustained proliferative signaling & evasion of growth suppressors

• Resisting Cell death
• Angiogenesis
• Invasion and metastasis
• Enabling replicative immortality
• Genomic Instability & Mutation
• Cancer Stem Cells
• EMT
• Resistance to immune response
• Tumor Promoting Inflammation
• Deregulation of cellular energetics

Introduction 

Introduce the hallmark of cancer providing essential biological basis and relevance in the study and treatment of cancer. Include a clarifying figure from a review/reference book to support the information provided. Include references.

Proposed Experiments 

Given the model and technique detailed, propose and critically justify one original experiment (i.e. designed and described by you) for the scientific investigation of the hallmark of cancer under study. This part should provide 1) information on how to set the experiment (which technique and experimental model, which intervention/treatment/comparison, etc); 2) aim and rationale of the experiments (“this experiment would allow the understanding of…”)

Brief Summary of Assessment Requirements

This assessment requires the student to prepare a professional briefing report for a newly established cancer research biotechnology company. The purpose is to demonstrate an understanding of one selected hallmark of cancer and evaluate how it can be scientifically investigated using appropriate study models and experimental techniques, with the long-term aim of informing product development.

Key Assessment Pointers

The assessment requires the student to:

1. Select one hallmark of cancer
   (e.g., Angiogenesis, Resisting Cell Death, Genomic Instability, EMT, etc.)
2. Introduction Section
   • Clearly introduce the chosen hallmark
   • Explain its biological basis and relevance in cancer development and treatment
   • Support explanations with a clarifying figure from peer-reviewed literature or reference textbooks
   • Use appropriate academic referencing
3. Critical Evaluation Section
   • Present one relevant study model (e.g., in vitro, in vivo, organoid, xenograft)
   • Present one experimental technique relevant to investigating the hallmark
   • Critically evaluate strengths, limitations, and relevance of both
4. Proposed Experiment Section
   • Design one original experiment
   • Clearly describe:
     • Experimental model and technique
     • Intervention, treatment, or comparison
     • Aim and scientific rationale
   • Justify how the experiment advances understanding of the selected hallmark

Academic Mentor’s Step-by-Step Approach

The academic mentor supported the student through a structured and methodical process, ensuring both scientific rigor and alignment with assessment criteria.

Step 1: Understanding the Brief and Industry Context

The mentor began by clarifying the biotech company perspective, emphasizing that the report must balance:

• Scientific accuracy
• Critical evaluation
• Translational relevance for product development

This helped the student understand that the task was not purely theoretical but applied in nature.

Step 2: Selecting the Hallmark of Cancer

The mentor guided the student to choose a hallmark that:

• Is well-researched in the literature
• Has clear experimental models and techniques available
• Offers scope for proposing a realistic experiment

The chosen hallmark was then clearly defined in scope to avoid overgeneralization.

Step 3: Structuring the Introduction

The mentor assisted in developing a concise yet biologically rich introduction by:

• Explaining the molecular mechanisms behind the hallmark
• Linking the hallmark to cancer progression and therapy resistance
• Guiding the selection of a high-quality review figure to visually support the explanation
• Ensuring proper academic referencing

Step 4: Selecting and Evaluating Study Model and Technique

The mentor helped the student:

• Identify one appropriate study model relevant to the hallmark
• Select one experimental technique commonly used in cancer research
• Critically assess:
  • Strengths and limitations
  • Biological relevance
  • Practical applicability in a biotech setting

This step strengthened the student’s analytical and evaluative skills.

Step 5: Designing the Original Experiment

The mentor guided the student in designing an original, hypothesis-driven experiment, focusing on:

• Clear experimental setup
• Logical choice of model and technique
• Defined intervention or comparison
• Strong scientific rationale explaining why the experiment is meaningful

The mentor emphasized originality while ensuring feasibility and alignment with real research practices.

Step 6: Refinement and Academic Coherence

Finally, the mentor reviewed the report structure to ensure:

• Logical flow between sections
• Clear linkage between hallmark, model, technique, and experiment
• Academic tone, clarity, and precision

Final Outcome and Learning Objectives Achieved

Outcome Achieved

• A well-structured briefing report aligned with biotech industry expectations
• Critical evaluation of cancer study models and experimental techniques
• A clearly justified, original experimental proposal grounded in literature

Learning Objectives Covered

• Understanding of cancer hallmarks and their biological significance
• Ability to critically evaluate research models and techniques
• Experimental design and scientific justification skills
• Application of theory to real-world research and product development
• Academic writing, referencing, and visual data interpretation

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